Diabetes and Pregnancy

What is diabetes mellitus?

Diabetes mellitus is a condition that causes high levels of glucose in the blood. Health problems can arise when glucose levels are too high.

What causes diabetes mellitus?

Diabetes is caused by a problem with insulin. Insulin moves glucose out of the blood and into the body's cells where it can be turned into energy. When the body does not make enough insulin or does not respond to it, glucose cannot get into cells and instead stays in the blood. High levels of glucose in the blood is called hyperglycemia. Over time, high blood glucose levels can damage the body and cause many problems, like heart disease, eye problems (including blindness), and kidney disease.

What are the types of diabetes mellitus and how are they treated?

There are two types of diabetes: type 1 and type 2. In type 1 diabetes, the body makes little or no insulin on its own. Type 1 diabetes is treated with insulin. A healthy diet and regular exercise also help keep blood glucose levels under control.

In type 2 diabetes, insulin is produced, but the body does not respond to it. More insulin is produced to keep glucose levels normal. Major risk factors for type 2 diabetes are obesity and family history. Type 2 diabetes often can be managed with a program of weight loss, diet, and exercise to maintain an ideal body weight. Oral medication or insulin sometimes may be needed.

What is pregestational diabetes mellitus?

Pregestational diabetes mellitus is diabetes that was present before pregnancy. About 1 in 100 women have pregestational diabetes.

How can pregestational diabetes mellitus affect pregnancy?

If a woman has medical conditions caused by her diabetes, pregnancy can make these conditions worse. Miscarriage and stillbirth are more common in pregnant women with diabetes. The risk of the following problems also is increased:

  • Hydramnios —This condition can lead to preterm labor and delivery.
  • Preeclampsia —This condition is linked to high blood pressure (see the FAQ Bleeding During Pregnancy).
  • Respiratory distress syndrome (RDS) —This syndrome can make it harder for the baby to breathe after birth.
  • Birth defects —Birth defects, most often involving the heart, brain, and skeleton, can occur.
  • Macrosomia (very large baby) —When the mother's glucose level is high throughout pregnancy, the baby can receive too much glucose. As a result, the baby can grow too large.

How can the risk of complications from diabetes during pregnancy be decreased?

The risks of these problems can be decreased if a woman maintains her blood glucose levels in the normal range before and during pregnancy. For this reason, getting medical care to prepare for pregnancy is essential for a woman with diabetes.

What is gestational diabetes mellitus?

Gestational diabetes is diabetes that occurs for the first time during pregnancy. Pregnancy changes the way insulin works. Some women develop gestational diabetes as a result of this change. Gestational diabetes is thought to affect 2-10% of all pregnancies.

What are risk factors for gestational diabetes?

Several risk factors are linked to gestational diabetes:

  • Age older than 25 years
  • Being overweight
  • History of gestational diabetes
  • Previous birth of a very large baby
  • A close relative with diabetes
  • Problems in a previous pregnancy (such as stillbirth)
  • Native-American, Asian, Hispanic, African American, or Pacific Islander ancestry
  • History of polycystic ovary syndrome

How can gestational diabetes mellitus affect pregnancy?

In women with gestational diabetes, high blood glucose levels during pregnancy increase the risk of having a very large baby and possible cesarean delivery. Preeclampsia also is more common in women with gestational diabetes.

How is diabetes mellitus managed during pregnancy?

Management of pregestational and gestational diabetes mellitus during pregnancy requires daily tracking of glucose levels, eating healthy foods, exercising regularly, and taking medication, if needed. Prenatal care also is important.

How are blood glucose levels tracked?

A glucose meter tests a small drop of blood. The drop of blood is placed on a strip of special paper. The glucose level then is read with the meter.

Do dosages of diabetes mellitus medication change during pregnancy?

Women with pregestational diabetes who took insulin before pregnancy usually need to increase their insulin dosage while they are pregnant. The insulin dosage may need to be adjusted throughout pregnancy.

Do women with diabetes mellitus need different prenatal care?

A woman with diabetes may need special tests in addition to routine health care. These tests can help your health care provider be aware of any problems and take steps to correct them. Some of the following tests may be done:

  1. Kick count —This is a record of how often you feel your baby move.
  2. Ultrasound exam —This exam checks how the baby is developing and whether any birth defects are apparent. It is used to help estimate fetal weight, locate the placenta, and assess the level of amniotic fluid.
  3. Fetal heart rate monitoring —The baby's heart rate is measured with a monitor that is placed on the mother's abdomen.
  4. Biophysical profile —This ultrasound test checks fetal breathing, fetal body movement, fetal muscle tone, and the amount of amniotic fluid.

How does diabetes mellitus affect labor and delivery?

Most women with diabetes are able to have a vaginal birth but are more likely to have a cesarean delivery than women without diabetes. Labor also may be induced (started by drugs or other means) earlier than the due date if problems with the pregnancy arise.

What problems can occur in babies born to mothers with diabetes mellitus?

After birth, most babies of women whose glucose is controlled do well. Some may need to spend time in a special care nursery. Problems can include

  • low glucose levels
  • low calcium and magnesium levels in the blood
  • jaundice (yellow color of the skin)
  • breathing problems

These problems can be treated soon after birth. If your glucose levels were controlled during your pregnancy, your baby is less likely to have problems after birth.

What special postpartum care is necessary for women with gestational diabetes mellitus?

One third of women who had gestational diabetes during pregnancy have diabetes or a milder form called glucose intolerance after giving birth. Up to one half will develop type 2 diabetes later in life. If you had gestational diabetes, you should have a test for diabetes 6-12 weeks after you give birth. In addition, the American Diabetes Association recommends that women who have had gestational diabetes and who had a normal postpartum glucose test result be tested for diabetes every 3 years.

Glossary

Amniotic Fluid:Water in the sac surrounding the fetus in the woman's uterus.

Biophysical Profile: An assessment by ultrasound of fetal breathing, fetal body movement, fetal muscle tone, and the amount of amniotic fluid. May include fetal heart rate. Sometimes the profile includes only the nonstress test and an estimate of the amount of amniotic fluid.

Cesarean Delivery: Delivery of a baby through an incision made in the mother's abdomen and uterus.

Insulin: A hormone that lowers the levels of glucose (sugar) in the blood.

Hydramnios: A condition in which there is an excess amount of amniotic fluid surrounding the fetus.

Miscarriage: Early pregnancy loss.

Obesity: A condition characterized by excessive body fat.

Placenta: Tissue that provides nourishment to and takes away waste from the fetus.

Polycystic Ovary Syndrome: A condition in which increased androgen levels occur and eggs are not released from the ovaries.

Preeclampsia: A condition of pregnancy in which there is high blood pressure and protein in the urine.

Preterm: Born before 37 weeks of pregnancy.

Respiratory Distress Syndrome (RDS): A condition of some babies in which the lungs are not mature, causing breathing difficulties.

Stillbirth: Delivery of a baby that shows no sign of life.

Ultrasound: A test in which sound waves are used to examine internal structures. During pregnancy, it can be used to examine the fetus.

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